FZD3 Antibody (PACO18492)
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주문- SKU:
- PACO18492
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FZD3 Antibody (PACO18492) |
Antibody SKU: | PACO18492 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human FZD3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18492(FZD3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18492(FZD3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. |
Synonyms: | frizzled family receptor 3 |
UniProt Protein Function: | FZD3: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p21 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: negative regulation of mitotic cell cycle, embryonic; neuron differentiation; positive regulation of neuroblast proliferation; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway |
NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9NPG1 |
NCBI GenInfo Identifier: | 17433071 |
NCBI Gene ID: | 7976 |
NCBI Accession: | Q9NPG1.1 |
UniProt Secondary Accession: | Q9NPG1,A8K615, |
UniProt Related Accession: | Q9NPG1 |
Molecular Weight: | – Da |
NCBI Full Name: | Frizzled-3 |
NCBI Synonym Full Names: | frizzled class receptor 3 |
NCBI Official Symbol: | FZD3 |
NCBI Official Synonym Symbols: | Fz-3 |
NCBI Protein Information: | frizzled-3 |
UniProt Protein Name: | Frizzled-3 |
UniProt Gene Name: | FZD3 |
UniProt Entry Name: | FZD3_HUMAN |
Antibodies | ELISA Kits |
Anti-FZD3 Antibody (CAB10063) | Human FZD3 / Frizzled-3 ELISA Kit |
FZD3 Antibody (PACO05375) | Human Frizzled-3 (FZD3) ELISA Kit |
FZD3 Antibody (PACO06490) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |