FZD10 Antibody (PACO55354)
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주문- SKU:
- PACO55354
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FZD10 Antibody (PACO55354) |
Antibody SKU: | PACO55354 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Frizzled-10 protein (125-225AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate. All lanes: FZD10 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 66 kDa. Observed band size: 66 kDa. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO55354 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO55354 at dilution of 1:100. |
Background: | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Synonyms: | Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350), FZD10 |
UniProt Protein Function: | FZD10: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: cell surface; cytoplasm; integral to plasma membrane Molecular Function:G-protein coupled receptor activity; protein binding; Wnt-protein binding Biological Process: neuron differentiation; positive regulation of GTPase activity; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin |
NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9ULW2 |
NCBI GenInfo Identifier: | 17433091 |
NCBI Gene ID: | 11211 |
NCBI Accession: | Q9ULW2.1 |
UniProt Related Accession: | Q9ULW2 |
Molecular Weight: | 65,336 Da |
NCBI Full Name: | Frizzled-10 |
NCBI Synonym Full Names: | frizzled class receptor 10 |
NCBI Official Symbol: | FZD10 |
NCBI Official Synonym Symbols: | Fz10; FzE7; CD350; FZ-10; hFz10 |
NCBI Protein Information: | frizzled-10 |
UniProt Protein Name: | Frizzled-10 |
UniProt Synonym Protein Names: | FzE7; CD_antigen: CD350 |
Protein Family: | Frizzled |
UniProt Gene Name: | FZD10 |
UniProt Entry Name: | FZD10_HUMAN |