UniProt Protein Function: | FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, Fz/Smo family; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 7q21 Cellular Component: cell surface; focal adhesion; integral to membrane; plasma membrane Molecular Function:frizzled binding; G-protein coupled receptor activity; PDZ domain binding; protein binding; receptor binding; Wnt receptor activity; Wnt-protein binding Biological Process: cell-cell signaling; neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; response to drug; synaptogenesis; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway |
NCBI Summary: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UP38 |
NCBI GenInfo Identifier: | 92058705 |
NCBI Gene ID: | 8321 |
NCBI Accession: | Q9UP38.2 |
UniProt Secondary Accession: | Q9UP38,O94815, Q549T8, A4D1E8, |
UniProt Related Accession: | Q9UP38 |
Molecular Weight: | 71,158 Da |
NCBI Full Name: | Frizzled-1 |
NCBI Synonym Full Names: | frizzled class receptor 1 |
NCBI Official Symbol: | FZD1 |
NCBI Protein Information: | frizzled-1 |
UniProt Protein Name: | Frizzled-1 |
UniProt Synonym Protein Names: | FzE1 |
Protein Family: | Frizzled |
UniProt Gene Name: | FZD1 |
UniProt Entry Name: | FZD1_HUMAN |