FTO Antibody (PACO16375)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO16375
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FTO Antibody (PACO16375) |
Antibody SKU: | PACO16375 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human FTO |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16375(FTO Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO16375(FTO Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16375(FTO Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. |
Synonyms: | fat mass and obesity associated |
UniProt Protein Function: | FTO: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD). A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years. Belongs to the fto family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.14.11.- Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: nuclear speck; nucleus Molecular Function:ferrous iron binding; DNA-N1-methyladenine dioxygenase activity Biological Process: DNA dealkylation; RNA repair; regulation of multicellular organism growth; thermoregulation Disease: Growth Retardation, Developmental Delay, Coarse Facies, And Early Death |
NCBI Summary: | This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011] |
UniProt Code: | Q9C0B1 |
NCBI GenInfo Identifier: | 148841515 |
NCBI Gene ID: | 79068 |
NCBI Accession: | Q9C0B1.3 |
UniProt Secondary Accession: | Q9C0B1,Q0P676, Q7Z785, A2RUH1, B2RNS0, |
UniProt Related Accession: | Q9C0B1 |
Molecular Weight: | 12,218 Da |
NCBI Full Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
NCBI Synonym Full Names: | fat mass and obesity associated |
NCBI Official Symbol: | FTO |
NCBI Official Synonym Symbols: | ALKBH9 |
NCBI Protein Information: | alpha-ketoglutarate-dependent dioxygenase FTO; protein fto; AlkB homolog 9; fat mass and obesity-associated protein |
UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
UniProt Synonym Protein Names: | Fat mass and obesity-associated protein |
Protein Family: | Alpha-ketoglutarate-dependent dioxygenase |
UniProt Gene Name: | FTO |
UniProt Entry Name: | FTO_HUMAN |
Antibodies | ELISA Kits |
Anti-FTO Antibody (CAB1438) | Human FTO (Alpha-ketoglutaRate-dependent dioxygenase FTO) ELISA Kit (HUFI05245) |
Anti-FTO Antibody (CAB3861) | |
FTO Antibody (PACO01752) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |