FSCN1 Antibody (PACO53850)
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주문- SKU:
- PACO53850
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FSCN1 Antibody (PACO53850) |
Antibody SKU: | PACO53850 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fascin protein (2-187AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: K562 whole cell lysate, HepG2 whole cell lysate. All lanes: FSCN1 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa. | |
Immunofluorescent analysis of HepG2 cells using PACO53850 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO53850 at dilution of 1:100. |
Background: | Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. |
Synonyms: | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55), FSCN1, FAN1 HSN SNL |
UniProt Protein Function: | Fascin: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding Chromosomal Location of Human Ortholog: 7p22 Cellular Component: cytoplasm; stress fiber; cell junction; cytosol; actin cytoskeleton; filopodium Molecular Function:protein binding, bridging; actin filament binding; protein binding; drug binding; actin binding Biological Process: cell proliferation; actin filament bundle formation; cell migration; cell motility involved in cell locomotion; actin cytoskeleton organization and biogenesis |
NCBI Summary: | This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q16658 |
NCBI GenInfo Identifier: | 2498357 |
NCBI Gene ID: | 6624 |
NCBI Accession: | Q16658.3 |
UniProt Related Accession: | Q16658 |
Molecular Weight: | 54kDa |
NCBI Full Name: | Fascin |
NCBI Synonym Full Names: | fascin actin-bundling protein 1 |
NCBI Official Symbol: | FSCN1 |
NCBI Official Synonym Symbols: | HSN; SNL; p55; FAN1 |
NCBI Protein Information: | fascin |
UniProt Protein Name: | Fascin |
UniProt Synonym Protein Names: | 55 kDa actin-bundling protein; Singed-like protein; p55 |
Protein Family: | Fascin |
UniProt Gene Name: | FSCN1 |
UniProt Entry Name: | FSCN1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |