FOXC1 Antibody (PACO17883)
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주문- SKU:
- PACO17883
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | FOXC1 Antibody (PACO17883) |
Antibody SKU: | PACO17883 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human FOXC1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: PACO17883(FOXC1 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
Background: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. |
Synonyms: | forkhead box C1 |
UniProt Protein Function: | FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1 |
NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12948 |
NCBI GenInfo Identifier: | 13638267 |
NCBI Gene ID: | 2296 |
NCBI Accession: | Q12948.3 |
UniProt Secondary Accession: | Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06, |
UniProt Related Accession: | Q12948 |
Molecular Weight: | 56,789 Da |
NCBI Full Name: | Forkhead box protein C1 |
NCBI Synonym Full Names: | forkhead box C1 |
NCBI Official Symbol: | FOXC1 |
NCBI Official Synonym Symbols: | ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 |
NCBI Protein Information: | forkhead box protein C1 |
UniProt Protein Name: | Forkhead box protein C1 |
UniProt Synonym Protein Names: | Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXC1 |
UniProt Entry Name: | FOXC1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |