FGF19 Antibody (PACO44376)
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주문- SKU:
- PACO44376
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | FGF19 Antibody (PACO44376) |
Antibody SKU: | PACO44376 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Fibroblast growth factor 19 protein (25-216AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: FGF19 antibody IgG at 3.26µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa.. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO44376 at dilution of 1:100. |
Background: | Involved in the suppression of bile acid, biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
Synonyms: | Fibroblast growth factor 19 (FGF-19), FGF19 |
UniProt Protein Function: | FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: extracellular region Molecular Function:protein binding; growth factor activity; fibroblast growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of glucose import; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; neural crest cell migration |
NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95750 |
NCBI GenInfo Identifier: | 11132196 |
NCBI Gene ID: | 9965 |
NCBI Accession: | O95750.1 |
UniProt Related Accession: | O95750 |
Molecular Weight: | 216 |
NCBI Full Name: | Fibroblast growth factor 19 |
NCBI Synonym Full Names: | fibroblast growth factor 19 |
NCBI Official Symbol: | FGF19 |
NCBI Protein Information: | fibroblast growth factor 19; FGF-19 |
UniProt Protein Name: | Fibroblast growth factor 19 |
Protein Family: | Fibroblast growth factor |
UniProt Gene Name: | FGF19 |
UniProt Entry Name: | FGF19_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |