FEM1B Antibody (PACO63515)
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주문- SKU:
- PACO63515
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FEM1B Antibody (PACO63515) |
Antibody SKU: | PACO63515 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Protein fem-1 homolog B protein (400-627AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: U87 whole cell lysate, Mouse heart tissue. All lanes: FEM1B antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71 kDa. Observed band size: 71 kDa. |
Background: | Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. |
Synonyms: | Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha), FEM1B, F1AA KIAA0396 |
UniProt Protein Function: | FEM1B: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Belongs to the fem-1 family. |
UniProt Protein Details: | Protein type:Apoptosis; Cell development/differentiation; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 15q23 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:death receptor binding; protein binding; ubiquitin-protein ligase activity Biological Process: regulation of ubiquitin-protein ligase activity |
NCBI Summary: | This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9UK73 |
NCBI GenInfo Identifier: | 74753369 |
NCBI Gene ID: | 10116 |
NCBI Accession: | Q9UK73.1 |
UniProt Secondary Accession: | Q9UK73,O43146, |
UniProt Related Accession: | Q9UK73 |
Molecular Weight: | 70kDa |
NCBI Full Name: | Protein fem-1 homolog B |
NCBI Synonym Full Names: | fem-1 homolog B |
NCBI Official Symbol: | FEM1B |
NCBI Official Synonym Symbols: | F1AA; F1A-ALPHA; FEM1-beta |
NCBI Protein Information: | protein fem-1 homolog B |
UniProt Protein Name: | Protein fem-1 homolog B |
UniProt Synonym Protein Names: | FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; F1A-alpha |
UniProt Gene Name: | FEM1B |