FBXO7 Antibody (PACO07458)
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주문- SKU:
- PACO07458
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FBXO7 Antibody (PACO07458) |
Antibody SKU: | PACO07458 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:10000 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide from AA range: 371-420 |
Form: | Liquid |
Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of mouse-kidney cells using Antibody diluted at 1000. |
Synonyms: | FBXO7 FBX7 |
UniProt Protein Function: | FBXO7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15); also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein binding; ubiquitin-protein ligase activity; protein kinase binding Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cyclin-dependent protein kinase activity; mitochondrion degradation; regulation of protein stability; protein ubiquitination; protein targeting to mitochondrion; negative regulation of lymphocyte differentiation Disease: Parkinson Disease 15, Autosomal Recessive Early-onset |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y3I1 |
NCBI GenInfo Identifier: | 13124249 |
NCBI Gene ID: | 25793 |
NCBI Accession: | Q9Y3I1.1 |
UniProt Secondary Accession: | Q9Y3I1,Q5TGC4, Q5TI86, Q96HM6, Q9UF21, Q9UKT2, B4DNB3 B4DWX5, |
UniProt Related Accession: | Q9Y3I1 |
Molecular Weight: | 522 |
NCBI Full Name: | F-box only protein 7 |
NCBI Synonym Full Names: | F-box protein 7 |
NCBI Official Symbol: | FBXO7 |
NCBI Official Synonym Symbols: | FBX; FBX7; PKPS; FBX07; PARK15 |
NCBI Protein Information: | F-box only protein 7 |
UniProt Protein Name: | F-box only protein 7 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO7 |
UniProt Entry Name: | FBX7_HUMAN |