FBXO31 Antibody (PACO19650)
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주문- SKU:
- PACO19650
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FBXO31 Antibody (PACO19650) |
Antibody SKU: | PACO19650 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human FBXO31 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19650(FBXO31 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19650(FBXO31 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. |
Synonyms: | F-box protein 31 |
UniProt Protein Function: | FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16q24.2 Cellular Component: cell soma; cytosol; SCF ubiquitin ligase complex Molecular Function:cyclin binding; ubiquitin-protein ligase activity Biological Process: cyclin catabolic process; G1 DNA damage checkpoint; protein polyubiquitination; response to DNA damage stimulus; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Disease: Mental Retardation, Autosomal Recessive 45 |
NCBI Summary: | This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q5XUX0 |
NCBI GenInfo Identifier: | 146345419 |
NCBI Gene ID: | 79791 |
NCBI Accession: | Q5XUX0.2 |
UniProt Secondary Accession: | Q5XUX0,Q5K680, Q8WYV1, Q96D73, Q9UFV4, |
UniProt Related Accession: | Q5XUX0 |
Molecular Weight: | 49,039 Da |
NCBI Full Name: | F-box only protein 31 |
NCBI Synonym Full Names: | F-box protein 31 |
NCBI Official Symbol: | FBXO31 |
NCBI Official Synonym Symbols: | FBX14; Fbx31; MRT45; FBXO14; pp2386 |
NCBI Protein Information: | F-box only protein 31 |
UniProt Protein Name: | F-box only protein 31 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO31 |
UniProt Entry Name: | FBX31_HUMAN |
Antibodies |
Anti-FBXO31 Antibody (CAB12888) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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