FAT1 Antibody (PACO19647)
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주문- SKU:
- PACO19647
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FAT1 Antibody (PACO19647) |
Antibody SKU: | PACO19647 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human FAT1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19647(FAT1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. |
Synonyms: | FAT atypical cadherin 1 |
UniProt Protein Function: | FAT: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q35 Cellular Component: filopodium; focal adhesion; integral to plasma membrane; intercellular junction; lamellipodium; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:calcium ion binding; protein binding Biological Process: actin filament organization; anatomical structure morphogenesis; cell adhesion; cell migration; cell-cell adhesion; cell-cell signaling; establishment and/or maintenance of cell polarity; homophilic cell adhesion |
NCBI Summary: | This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14517 |
NCBI GenInfo Identifier: | 66346693 |
NCBI Gene ID: | 2195 |
NCBI Accession: | NP_005236.2 |
UniProt Related Accession: | Q14517 |
Molecular Weight: | 506,273 Da |
NCBI Full Name: | protocadherin Fat 1 |
NCBI Synonym Full Names: | FAT atypical cadherin 1 |
NCBI Official Symbol: | FAT1 |
NCBI Official Synonym Symbols: | FAT; ME5; CDHF7; CDHR8; hFat1 |
NCBI Protein Information: | protocadherin Fat 1 |
UniProt Protein Name: | Protocadherin Fat 1 |
UniProt Synonym Protein Names: | Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homolog |
Protein Family: | Fatty acid transporter protein |
UniProt Gene Name: | FAT1 |
UniProt Entry Name: | FAT1_HUMAN |
Antibodies |
Anti-FAT1 Antibody (CAB14681) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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