FAR1 Antibody (PACO61081)
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주문- SKU:
- PACO61081
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FAR1 Antibody (PACO61081) |
Antibody SKU: | PACO61081 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fatty acyl-CoA reductase 1 protein (182-343AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO61081 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO61081 diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). |
Synonyms: | Fatty acyl-CoA reductase 1 (EC 1.2.1.84) (Male sterility domain-containing protein 2), FAR1, MLSTD2 |
UniProt Protein Function: | MLSTD2: Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. Belongs to the fatty acyl-CoA reductase family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Membrane protein, integral; EC 1.2.1.n2 Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: peroxisomal matrix; peroxisomal membrane; peroxisome Molecular Function:oxidoreductase activity Biological Process: ether lipid biosynthetic process; glycerophospholipid biosynthetic process; wax biosynthetic process Disease: Peroxisomal Fatty Acyl-coa Reductase 1 Disorder |
NCBI Summary: | The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015] |
UniProt Code: | Q8WVX9 |
NCBI GenInfo Identifier: | 33872399 |
NCBI Gene ID: | 84188 |
NCBI Accession: | BC017377 |
UniProt Secondary Accession: | Q8WVX9,Q5CZA3, D3DQW8, |
UniProt Related Accession: | Q8WVX9 |
Molecular Weight: | 59,357 Da |
NCBI Full Name: | Homo sapiens fatty acyl CoA reductase 1, mRNA |
NCBI Synonym Full Names: | fatty acyl-CoA reductase 1 |
NCBI Official Symbol: | FAR1 |
NCBI Official Synonym Symbols: | PFCRD; MLSTD2; SDR10E1 |
NCBI Protein Information: | fatty acyl-CoA reductase 1 |
UniProt Protein Name: | Fatty acyl-CoA reductase 1 |
UniProt Synonym Protein Names: | Male sterility domain-containing protein 2 |
Protein Family: | Fatty acyl-CoA reductase |
UniProt Gene Name: | FAR1 |
UniProt Entry Name: | FACR1_HUMAN |
Antibodies |
Anti-FAR1 Antibody (CAB16284) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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