F11R Antibody (PACO16563)
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주문- SKU:
- PACO16563
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | F11R Antibody (PACO16563) |
Antibody SKU: | PACO16563 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human F11R |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16563(F11R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, human kidney cancer tissue, 293T cells, HepG2 cells, Primary antibody: PACO16563(F11R Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16563(F11R Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. |
Synonyms: | F11 receptor |
UniProt Protein Function: | JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.2-q21.3 Cellular Component: microtubule cytoskeleton; tight junction; plasma membrane; integral to membrane; cytoplasmic vesicle; intercellular junction; cell junction Molecular Function:protein binding; PDZ domain binding Biological Process: intercellular junction assembly and maintenance; response to radiation; extracellular matrix organization and biogenesis; viral reproduction; transforming growth factor beta receptor signaling pathway; actomyosin structure organization and biogenesis; cell adhesion; blood coagulation; inflammatory response; leukocyte migration; positive regulation of blood pressure; intestinal absorption |
NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y624 |
NCBI GenInfo Identifier: | 10720061 |
NCBI Gene ID: | 50848 |
NCBI Accession: | Q9Y624.1 |
UniProt Secondary Accession: | Q9Y624,B7Z941, |
UniProt Related Accession: | Q9Y624 |
Molecular Weight: | 299 |
NCBI Full Name: | Junctional adhesion molecule A |
NCBI Synonym Full Names: | F11 receptor |
NCBI Official Symbol: | F11R |
NCBI Official Synonym Symbols: | JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1 |
NCBI Protein Information: | junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1 |
UniProt Protein Name: | Junctional adhesion molecule A |
UniProt Synonym Protein Names: | Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321 |
Protein Family: | Junctional adhesion molecule |
UniProt Gene Name: | F11R |
UniProt Entry Name: | JAM1_HUMAN |