ETFB Antibody (PACO19624)
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주문- SKU:
- PACO19624
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ETFB Antibody (PACO19624) |
Antibody SKU: | PACO19624 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human ETFB |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19624(ETFB Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, Hela cells, Primary antibody: PACO19624(ETFB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19624(ETFB Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes electron-transfer-flavoprotein, β polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid, and amino acid, catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricacid, ria. Alternatively spliced transcript variants have been found for this gene. |
Synonyms: | electron-transfer-flavoprotein, β polypeptide |
UniProt Protein Function: | ETFB: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B). GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF beta-subunit/FixA family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix Molecular Function:electron carrier activity Biological Process: cellular metabolic process Disease: Multiple Acyl-coa Dehydrogenase Deficiency |
NCBI Summary: | This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P38117 |
NCBI GenInfo Identifier: | 62420877 |
NCBI Gene ID: | 2109 |
NCBI Accession: | NP_001014763.1 |
UniProt Secondary Accession: | P38117,Q6IBH7, Q71RF6, Q9Y3S7, B3KNY2, |
UniProt Related Accession: | P38117 |
Molecular Weight: | 37,566 Da |
NCBI Full Name: | electron transfer flavoprotein subunit beta isoform 2 |
NCBI Synonym Full Names: | electron-transfer-flavoprotein, beta polypeptide |
NCBI Official Symbol: | ETFB |
NCBI Official Synonym Symbols: | MADD; FP585 |
NCBI Protein Information: | electron transfer flavoprotein subunit beta; beta-ETF; electron transfer flavoprotein beta subunit; electron transfer flavoprotein beta-subunit; electron transfer flavoprotein, beta polypeptide; electron-transferring-flavoprotein, beta polypeptide |
UniProt Protein Name: | Electron transfer flavoprotein subunit beta |
Protein Family: | Electron transfer flavoprotein |
UniProt Gene Name: | ETFB |
UniProt Entry Name: | ETFB_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |