ERP29 Antibody (PACO31956)
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주문- SKU:
- PACO31956
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ERP29 Antibody (PACO31956) |
Antibody SKU: | PACO31956 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Endoplasmic reticulum resident protein 29 protein (40-251AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: ERP29 antibody at 2‚µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 29, 6 kDa Observed band size: 29, 55 kDa . | |
Immunohistochemistry of paraffin-embedded human prostate tissue using PACO31956 at dilution of 1:100. |
Background: | Proper protein folding and post-translational modifications are essential for secretory protein export out of the endoplasmic reticulum. This task is accomplished by chaperone proteins such as protein disulfide isomerase (PDI), GRP94, and BiP. A recently characterized protein, designated ERp29, is closely related to these chaperone proteins and appears to be upregulated during ER stress conditions. ERp29 is a soluble 259-residue protein that is localized to the lumen of the endoplasmic reticulum in all mammalian cells. Research has shown that there are two primary domains within ERp29. The first is the C-terminal region that is a novel, all helical, fold that is most likely involved with ERp29 retention to the ER. The second is the N-terminal region that resembles that of PDI‚‚’s thioredoxin module. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. |
Synonyms: | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31), ERP29, C12orf8 ERP28 |
UniProt Protein Function: | ERP29: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. |
UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 12q24.13 Cellular Component: cell surface; endoplasmic reticulum; membrane; smooth endoplasmic reticulum; transport vesicle Molecular Function:chaperone binding; protein disulfide isomerase activity; protein homodimerization activity Biological Process: activation of MAPK activity; intracellular protein transport; negative regulation of protein secretion; positive regulation of protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30040 |
NCBI GenInfo Identifier: | 6015110 |
NCBI Gene ID: | 10961 |
NCBI Accession: | P30040.4 |
UniProt Secondary Accession: | P30040,Q3MJC3, Q6FHT4, C9J183, |
UniProt Related Accession: | P30040 |
Molecular Weight: | 5,477 Da |
NCBI Full Name: | Endoplasmic reticulum resident protein 29 |
NCBI Synonym Full Names: | endoplasmic reticulum protein 29 |
NCBI Official Symbol: | ERP29 |
NCBI Official Synonym Symbols: | ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107 |
NCBI Protein Information: | endoplasmic reticulum resident protein 29 |
UniProt Protein Name: | Endoplasmic reticulum resident protein 29 |
UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 28; ERp28; Endoplasmic reticulum resident protein 31; ERp31 |
Protein Family: | Endoplasmic reticulum resident protein |
UniProt Gene Name: | ERP29 |
UniProt Entry Name: | ERP29_HUMAN |