ERO1LB Antibody (PACO09141)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO09141
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ERO1LB Antibody (PACO09141) |
Antibody SKU: | PACO09141 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse |
Immunogen: | Human ERO1LB |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ERO1-like β (S. cerevisiae); |
UniProt Protein Function: | ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.8.4.-; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 1q42.2-q43 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum Molecular Function:protein binding; unfolded protein binding; protein disulfide oxidoreductase activity; protein disulfide isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor Biological Process: insulin processing; protein maturation via protein folding; extracellular matrix organization and biogenesis; 4-hydroxyproline metabolic process; protein folding; cell redox homeostasis; glucose homeostasis |
UniProt Code: | Q86YB8 |
NCBI GenInfo Identifier: | 116241353 |
NCBI Gene ID: | 56605 |
NCBI Accession: | Q86YB8.2 |
UniProt Secondary Accession: | Q86YB8,Q5T1H4, Q8IZ11, Q9NR62, B4DF57, |
UniProt Related Accession: | Q86YB8 |
Molecular Weight: | |
NCBI Full Name: | ERO1-like protein beta |
NCBI Synonym Full Names: | ERO1-like beta (S. cerevisiae) |
NCBI Official Symbol: | ERO1LB |
NCBI Protein Information: | ERO1-like protein beta; ERO1-L-beta; endoplasmic oxidoreductin-1-like protein B; endoplasmic reticulum oxidoreductin-1-like protein B; oxidoreductin-1-L-beta |
UniProt Protein Name: | ERO1-like protein beta |
UniProt Synonym Protein Names: | Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta |
UniProt Gene Name: | ERO1LB |
UniProt Entry Name: | ERO1B_HUMAN |