ERG Antibody (PACO14495)
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주문- SKU:
- PACO14495
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ERG Antibody (PACO14495) |
Antibody SKU: | PACO14495 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ERG |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14495(ERG Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO14495(ERG Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14495(ERG Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms: | V-ets erythroblastosis virus E26 oncogene homolog (avian) |
UniProt Protein Function: | ERG: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4. Belongs to the ETS family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cytoplasm; nucleus; ribonucleoprotein complex Molecular Function:signal transducer activity; protein binding; DNA binding; sequence-specific DNA binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; multicellular organismal development; cell differentiation; signal transduction; protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014] |
UniProt Code: | P11308 |
NCBI GenInfo Identifier: | 152031600 |
NCBI Gene ID: | 2078 |
NCBI Accession: | P11308.2 |
UniProt Related Accession: | P11308 |
Molecular Weight: | 57.8 |
NCBI Full Name: | Transcriptional regulator ERG |
NCBI Synonym Full Names: | ETS transcription factor ERG |
NCBI Official Symbol: | ERG |
NCBI Official Synonym Symbols: | p55; erg-3 |
NCBI Protein Information: | transcriptional regulator ERG |
UniProt Protein Name: | Transcriptional regulator ERG |
UniProt Synonym Protein Names: | Transforming protein ERG |
Protein Family: | Transcriptional regulator |
UniProt Gene Name: | ERG |
UniProt Entry Name: | ERG_HUMAN |