ERAP2 Antibody (PACO62271)
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주문- SKU:
- PACO62271
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ERAP2 Antibody (PACO62271) |
Antibody SKU: | PACO62271 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO62271 diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. |
Synonyms: | Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11) (Leukocyte-derived arginine aminopeptidase) (L-RAP), ERAP2, LRAP |
UniProt Protein Function: | ERAP2: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. Belongs to the peptidase M1 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral; Protease; EC 3.4.11.- Chromosomal Location of Human Ortholog: 5q15 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; integral to membrane Molecular Function:metallopeptidase activity; zinc ion binding; aminopeptidase activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; regulation of blood pressure; proteolysis; antigen processing and presentation of endogenous peptide antigen via MHC class I |
NCBI Summary: | Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6P179 |
NCBI GenInfo Identifier: | 194306629 |
NCBI Gene ID: | 64167 |
NCBI Accession: | NP_001123612.1 |
UniProt Secondary Accession: | Q6P179,Q7Z5K1, Q8TD32, Q8WVJ4, Q9HBX2, |
UniProt Related Accession: | Q6P179 |
Molecular Weight: | Predicted: 30.0kDaAccurate: 34kDa as determined by SDS-PAGE reducing conditions. |
NCBI Full Name: | endoplasmic reticulum aminopeptidase 2 |
NCBI Synonym Full Names: | endoplasmic reticulum aminopeptidase 2 |
NCBI Official Symbol: | ERAP2 |
NCBI Official Synonym Symbols: | LRAP; L-RAP |
NCBI Protein Information: | endoplasmic reticulum aminopeptidase 2 |
UniProt Protein Name: | Endoplasmic reticulum aminopeptidase 2 |
UniProt Synonym Protein Names: | Leukocyte-derived arginine aminopeptidase; L-RAP |
Protein Family: | Endoplasmic reticulum aminopeptidase |
UniProt Gene Name: | ERAP2 |
UniProt Entry Name: | ERAP2_HUMAN |
Antibodies | ELISA Kits |
Anti-ERAP2 Antibody (CAB9024) | Human ERAP2 (Endoplasmic reticulum aminopeptidase 2) ELISA Kit (HUFI04417) |
ERAP2 Antibody (PACO09121) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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