EPHX1 Antibody (PACO13783)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO13783
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EPHX1 Antibody (PACO13783) |
Antibody SKU: | PACO13783 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:500-1:2000, IHC:1:10-1:25 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human EPHX1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO13783(EPHX1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. |
Synonyms: | Epoxide hydrolase 1 |
UniProt Protein Function: | Ephx1: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. Defects in EPHX1 are a cause of familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the peptidase S33 family. |
UniProt Protein Details: | Protein type:EC 3.3.2.9; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity Biological Process: response to toxin; response to organic cyclic substance; aromatic compound catabolic process Disease: Hypercholanemia, Familial; Preeclampsia/eclampsia 1 |
NCBI Summary: | Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008] |
UniProt Code: | P07099 |
NCBI GenInfo Identifier: | 123926 |
NCBI Gene ID: | 2052 |
NCBI Accession: | P07099.1 |
UniProt Secondary Accession: | P07099,Q5VTJ6, Q9NP75, Q9NPE7, Q9NQU6, Q9NQU7, Q9NQU8 Q9NQU9, Q9NQV0, Q9NQV1, Q9NQV2, B2R8N0, |
UniProt Related Accession: | P07099 |
Molecular Weight: | 455 |
NCBI Full Name: | Epoxide hydrolase 1 |
NCBI Synonym Full Names: | epoxide hydrolase 1, microsomal (xenobiotic) |
NCBI Official Symbol: | EPHX1 |
NCBI Official Synonym Symbols: | MEH; EPHX; EPOX; HYL1 |
NCBI Protein Information: | epoxide hydrolase 1; epoxide hydratase |
UniProt Protein Name: | Epoxide hydrolase 1 |
UniProt Synonym Protein Names: | Epoxide hydratase; Microsomal epoxide hydrolase |
UniProt Gene Name: | EPHX1 |
UniProt Entry Name: | HYEP_HUMAN |
Antibodies |
Anti-EPHX1 Antibody (CAB2070) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |