EPHB6 Antibody (PACO47402)
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주문- SKU:
- PACO47402
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EPHB6 Antibody (PACO47402) |
Antibody SKU: | PACO47402 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Ephrin type-B receptor 6 protein (410-553AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse skeletal muscle tissue. All lanes: EPHB6 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 111, 82, 58 kDa. Observed band size: 111 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO47402 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO47402 at dilution of 1:100. |
Background: | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. |
Synonyms: | Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6), EPHB6 |
UniProt Protein Function: | EphB6: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Eph family Chromosomal Location of Human Ortholog: 7q33-q35 Cellular Component: cytosol; extracellular region; plasma membrane Molecular Function:receptor activity Biological Process: ephrin receptor signaling pathway |
NCBI Summary: | This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | O15197 |
NCBI GenInfo Identifier: | 294862532 |
NCBI Gene ID: | 2051 |
NCBI Accession: | O15197.4 |
UniProt Secondary Accession: | O15197,Q2TB23, Q2TB24, A4D2I7, A8CDT5, D3DXD3, |
UniProt Related Accession: | O15197 |
Molecular Weight: | 57,498 Da |
NCBI Full Name: | Ephrin type-B receptor 6 |
NCBI Synonym Full Names: | EPH receptor B6 |
NCBI Official Symbol: | EPHB6 |
NCBI Official Synonym Symbols: | HEP |
NCBI Protein Information: | ephrin type-B receptor 6 |
UniProt Protein Name: | Ephrin type-B receptor 6 |
UniProt Synonym Protein Names: | HEP; Tyrosine-protein kinase-defective receptor EPH-6 |
Protein Family: | Ephrin type-B receptor |
UniProt Gene Name: | EPHB6 |
UniProt Entry Name: | EPHB6_HUMAN |
Antibodies | ELISA Kits |
Anti-EPHB6 Antibody (CAB14728) | EPHB6 Colorimetric Cell-Based ELISA Kit |
Anti-EPHB6 Antibody (CAB14729) | |
EPHB6 Antibody (PACO00765) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |