EPHA1 Antibody (PACO13445)
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주문- SKU:
- PACO13445
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EPHA1 Antibody (PACO13445) |
Antibody SKU: | PACO13445 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse |
Immunogen: | Human EPHA1-special |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | EPH receptor A1;EPHA1;EPH;EPHT;EPHT1;MGC163163 ; |
UniProt Protein Function: | EphA1: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Misexpressed in several cancers, including upregulation in head and neck cancer, and downregulation in invasive breast cancer cell lines and glioblastoma |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; TK group; Eph family Chromosomal Location of Human Ortholog: 7q34 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity Biological Process: angiogenesis; cell surface receptor linked signal transduction; ephrin receptor signaling pathway; negative regulation of cell migration; negative regulation of protein kinase activity; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of stress fiber formation; protein amino acid autophosphorylation; regulation of GTPase activity; somatic stem cell maintenance |
NCBI Summary: | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21709 |
NCBI GenInfo Identifier: | 317373566 |
NCBI Gene ID: | 2041 |
NCBI Accession: | P21709.4 |
UniProt Secondary Accession: | P21709,Q15405, A1L3V3, B5A966, B5A967, |
UniProt Related Accession: | P21709 |
Molecular Weight: | 51,069 Da |
NCBI Full Name: | Ephrin type-A receptor 1 |
NCBI Synonym Full Names: | EPH receptor A1 |
NCBI Official Symbol: | EPHA1 |
NCBI Official Synonym Symbols: | EPH; EPHT; EPHT1 |
NCBI Protein Information: | ephrin type-A receptor 1 |
UniProt Protein Name: | Ephrin type-A receptor 1 |
UniProt Synonym Protein Names: | EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH |
Protein Family: | Ephrin type-A receptor |
UniProt Gene Name: | EPHA1 |
UniProt Entry Name: | EPHA1_HUMAN |