EME1 Antibody (PACO40086)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO40086
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EME1 Antibody (PACO40086) |
Antibody SKU: | PACO40086 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO40086 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO40086 at dilution of 1:100. |
Background: | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. |
Synonyms: | Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4), EME1, MMS4 |
UniProt Protein Function: | EME1: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the EME1/MMS4 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus; EC 3.1.22.-; Deoxyribonuclease Chromosomal Location of Human Ortholog: 17q21.33 Cellular Component: cytoplasm; nucleolus; nuclear heterochromatin; nucleus Molecular Function:protein binding; DNA binding; metal ion binding; endonuclease activity Biological Process: DNA repair; DNA recombination |
NCBI Summary: | This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] |
UniProt Code: | Q96AY2 |
NCBI GenInfo Identifier: | 260764007 |
NCBI Gene ID: | 146956 |
NCBI Accession: | NP_689676.2 |
UniProt Secondary Accession: | Q96AY2,Q96N62, |
UniProt Related Accession: | Q96AY2 |
Molecular Weight: | 64,779 Da |
NCBI Full Name: | crossover junction endonuclease EME1 isoform 2 |
NCBI Synonym Full Names: | essential meiotic structure-specific endonuclease 1 |
NCBI Official Symbol: | EME1 |
NCBI Official Synonym Symbols: | MMS4L; SLX2A |
NCBI Protein Information: | crossover junction endonuclease EME1; hMMS4; MMS4 homolog; homolog of yeast EME1 endonuclease; essential meiotic endonuclease 1 homolog 1; essential meiotic endonuclease 1 homolog 2; SLX2 structure-specific endonuclease subunit homolog A |
UniProt Protein Name: | Crossover junction endonuclease EME1 |
UniProt Synonym Protein Names: | MMS4 homolog; hMMS4 |
Protein Family: | Crossover junction endonuclease |
UniProt Gene Name: | EME1 |
UniProt Entry Name: | EME1_HUMAN |