ELP2 Antibody (PACO15736)
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주문- SKU:
- PACO15736
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ELP2 Antibody (PACO15736) |
Antibody SKU: | PACO15736 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Fusion protein of human ELP2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15736(ELP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15736(ELP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate. |
Synonyms: | elongator acetyltransferase complex subunit 2 |
UniProt Protein Function: | ELP2: Regulates the ligand-dependent activation of STAT3. Belongs to the WD repeat ELP2 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18q12.2 Cellular Component: cytoplasm; Elongator holoenzyme complex; histone acetyltransferase complex; transcription elongation factor complex; transcriptional repressor complex Molecular Function:histone binding Biological Process: regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016] |
UniProt Code: | Q6IA86 |
NCBI GenInfo Identifier: | 83305834 |
NCBI Gene ID: | 55250 |
NCBI Accession: | Q6IA86.2 |
UniProt Secondary Accession: | Q6IA86,Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0 A8KAI6, B4DTG0, B4DXP0, E7EP23, E9PCX0, |
UniProt Related Accession: | Q6IA86 |
Molecular Weight: | 84,688 Da |
NCBI Full Name: | Elongator complex protein 2 |
NCBI Synonym Full Names: | elongator acetyltransferase complex subunit 2 |
NCBI Official Symbol: | ELP2 |
NCBI Official Synonym Symbols: | StIP; SHINC-2; STATIP1 |
NCBI Protein Information: | elongator complex protein 2 |
UniProt Protein Name: | Elongator complex protein 2 |
UniProt Synonym Protein Names: | SHINC-2; STAT3-interacting protein 1; StIP1 |
Protein Family: | Elongator complex protein |
UniProt Gene Name: | ELP2 |
UniProt Entry Name: | ELP2_HUMAN |