ELAC2 Antibody (PACO16249)
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주문- SKU:
- PACO16249
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ELAC2 Antibody (PACO16249) |
Antibody SKU: | PACO16249 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ELAC2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A375 cells, LoVo cells, human testis tissue, Hela cells, Primary antibody: PACO16249(ELAC2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
Background: | The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-β induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | elaC ribonuclease Z 2 |
UniProt Protein Function: | ELAC2: a zinc phosphodiesterase. Putative prostate cancer susceptibility protein. |
UniProt Protein Details: | Protein type:Ribonuclease; Oncoprotein; RNA processing; EC 3.1.26.11; Phosphodiesterase Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; mitochondrion; nucleus Molecular Function:metal ion binding; endonuclease activity Disease: Prostate Cancer, Hereditary, 2; Combined Oxidative Phosphorylation Deficiency 17 |
NCBI Summary: | The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q9BQ52 |
NCBI GenInfo Identifier: | 41017788 |
NCBI Gene ID: | 60528 |
NCBI Accession: | Q9BQ52.2 |
UniProt Secondary Accession: | Q9BQ52,Q6IA94, Q9HAS8, Q9HAS9, Q9NVT1, B4DPL9, |
UniProt Related Accession: | Q9BQ52 |
Molecular Weight: | 826 |
NCBI Full Name: | Zinc phosphodiesterase ELAC protein 2 |
NCBI Synonym Full Names: | elaC ribonuclease Z 2 |
NCBI Official Symbol: | ELAC2 |
NCBI Official Synonym Symbols: | ELC2; HPC2; COXPD17 |
NCBI Protein Information: | zinc phosphodiesterase ELAC protein 2; RNase Z 2; tRNase Z 2; elaC homolog 2; ribonuclease Z 2; tRNase Z (long form); tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2 |
UniProt Protein Name: | Zinc phosphodiesterase ELAC protein 2 |
UniProt Synonym Protein Names: | ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2 |
Protein Family: | Zinc phosphodiesterase ELAC protein |
UniProt Gene Name: | ELAC2 |
UniProt Entry Name: | RNZ2_HUMAN |