EIF4E Antibody (PACO47390)
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주문- SKU:
- PACO47390
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EIF4E Antibody (PACO47390) |
Antibody SKU: | PACO47390 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Eukaryotic translation initiation factor 4E protein (2-217AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO47390 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO47390 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
Synonyms: | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein), EIF4E, EIF4EL1 EIF4F |
UniProt Protein Function: | EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. |
UniProt Protein Details: | Protein type:Translation initiation; Translation Chromosomal Location of Human Ortholog: 4q23 Cellular Component: mRNA cap complex; stress granule; eukaryotic translation initiation factor 4F complex; cytoplasm; cytosol Molecular Function:protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity; RNA cap binding Biological Process: viral reproduction; translation; cytokine and chemokine mediated signaling pathway; positive regulation of mitotic cell cycle; regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; insulin receptor signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; G1/S transition of mitotic cell cycle; lung development Disease: Autism, Susceptibility To, 19 |
NCBI Summary: | The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | P06730 |
NCBI GenInfo Identifier: | 1352435 |
NCBI Gene ID: | 1977 |
NCBI Accession: | P06730.2 |
UniProt Secondary Accession: | P06730,Q96E95, B7Z6V1, D6RCQ6, |
UniProt Related Accession: | P06730 |
Molecular Weight: | 27,260 Da |
NCBI Full Name: | Eukaryotic translation initiation factor 4E |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 4E |
NCBI Official Symbol: | EIF4E |
NCBI Official Synonym Symbols: | CBP; EIF4F; AUTS19; EIF4E1; EIF4EL1 |
NCBI Protein Information: | eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; eukaryotic translation initiation factor 4E-like 1; mRNA cap-binding protein |
UniProt Protein Name: | Eukaryotic translation initiation factor 4E |
UniProt Synonym Protein Names: | eIF-4F 25 kDa subunit; mRNA cap-binding protein |
Protein Family: | Eukaryotic translation initiation factor |
UniProt Gene Name: | EIF4E |
UniProt Entry Name: | IF4E_HUMAN |
Antibodies |
Anti-EIF4E Antibody (CAB0468) |
Anti-EIF4E Antibody (CAB2162) |
Anti-EIF4E Antibody (CAB6085) |
Anti-Phospho-eIF4E-S209 Antibody (CABP0747) |
Anti-EIF4E Antibody (CAB19044) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |