EIF2AK3 Antibody (PACO14869)
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주문- SKU:
- PACO14869
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EIF2AK3 Antibody (PACO14869) |
Antibody SKU: | PACO14869 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human EIF2AK3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14869(EIF2AK3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14869(EIF2AK3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene phosphorylates the α subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
Synonyms: | eukaryotic translation initiation factor 2-α kinase 3 |
NCBI Summary: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9NZJ5 |
NCBI GenInfo Identifier: | 296439367 |
NCBI Gene ID: | 9451 |
NCBI Accession: | |
UniProt Related Accession: | Q9NZJ5 |
Molecular Weight: | 170 |
NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 3 |
NCBI Official Symbol: | EIF2AK3 |
NCBI Official Synonym Symbols: | PEK; WRS; PERK |
NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 3 |
UniProt Protein Name: | |
UniProt Gene Name: |
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