UniProt Protein Function: | EGFL7: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro. |
UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:calcium ion binding; Notch binding Biological Process: blood vessel development; negative regulation of Notch signaling pathway; positive regulation of endothelial cell proliferation; angiogenesis; cell adhesion; vasculogenesis; negative regulation of cell migration |
NCBI Summary: | This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9UHF1 |
NCBI GenInfo Identifier: | 92090985 |
NCBI Gene ID: | 51162 |
NCBI Accession: | Q9UHF1.3 |
UniProt Secondary Accession: | Q9UHF1,Q5M7Y5, Q5VUD5, Q96EG0, B3KRP0, M9VTX9, |
UniProt Related Accession: | Q9UHF1 |
Molecular Weight: | 29,618 Da |
NCBI Full Name: | Epidermal growth factor-like protein 7 |
NCBI Synonym Full Names: | EGF-like-domain, multiple 7 |
NCBI Official Symbol: | EGFL7 |
NCBI Official Synonym Symbols: | NEU1; ZNEU1; VE-STATIN |
NCBI Protein Information: | epidermal growth factor-like protein 7; EGF-like protein 7; NOTCH4-like protein; vascular endothelial statin; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domains protein 7 |
UniProt Protein Name: | Epidermal growth factor-like protein 7 |
UniProt Synonym Protein Names: | Multiple epidermal growth factor-like domains protein 7; Multiple EGF-like domains protein 7; NOTCH4-like protein; Vascular endothelial statin; VE-statin; Zneu1 |
Protein Family: | Epidermal growth factor-like protein |
UniProt Gene Name: | EGFL7 |
UniProt Entry Name: | EGFL7_HUMAN |