EDN2 Antibody (PACO14403)
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주문- SKU:
- PACO14403
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EDN2 Antibody (PACO14403) |
Antibody SKU: | PACO14403 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human EDN2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14403(EDN2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. |
Synonyms: | endothelin 2 |
UniProt Protein Function: | EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p34 Cellular Component: extracellular region; extracellular space Molecular Function:endothelin B receptor binding; hormone activity Biological Process: artery smooth muscle contraction; calcium-mediated signaling; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; hormonal regulation of the force of heart contraction; inositol phosphate-mediated signaling; macrophage activation; macrophage chemotaxis; neutrophil chemotaxis; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of leukocyte chemotaxis; positive regulation of the force of heart contraction by chemical signal; prostaglandin biosynthetic process; regulation of systemic arterial blood pressure by endothelin; vasoconstriction; vein smooth muscle contraction |
NCBI Summary: | This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
UniProt Code: | P20800 |
NCBI GenInfo Identifier: | 119615 |
NCBI Gene ID: | 1907 |
NCBI Accession: | P20800.2 |
UniProt Secondary Accession: | P20800,Q5T1R3, |
UniProt Related Accession: | P20800 |
Molecular Weight: | 19,960 Da |
NCBI Full Name: | Endothelin-2 |
NCBI Synonym Full Names: | endothelin 2 |
NCBI Official Symbol: | EDN2 |
NCBI Official Synonym Symbols: | ET2; ET-2; PPET2 |
NCBI Protein Information: | endothelin-2 |
UniProt Protein Name: | Endothelin-2 |
UniProt Synonym Protein Names: | Preproendothelin-2; PPET2 |
Protein Family: | Endothelin |
UniProt Gene Name: | EDN2 |
UniProt Entry Name: | EDN2_HUMAN |
Antibodies | ELISA Kits |
EDN2 Antibody (PACO08995) | Human Endothelin-2 / ET-2 ELISA Kit |
Human Endothelin-2 (EDN2) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |