DYSF Antibody (PACO23103)
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주문- SKU:
- PACO23103
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DYSF Antibody (PACO23103) |
Antibody SKU: | PACO23103 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from human Dysferlin. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from K562 cells, using Dysferlin antibody. | |
Western blot analysis of extracts from JK cells (Lane 2) and K562 cells (Lane 3), using Dysferlin antiobdy. The lane on the left is treated with synthesized peptide. |
Background: | Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress By similarity. |
Synonyms: | dysferlin; limb girdle muscular dystrophy 2B (autosomal recessive); |
UniProt Protein Function: | Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
NCBI Summary: | The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008] |
UniProt Code: | O75923 |
NCBI GenInfo Identifier: | 195976821 |
NCBI Gene ID: | 8291 |
NCBI Accession: | NP_001123927.1 |
UniProt Secondary Accession: | O75923,A0FK00, B1PZ70, B1PZ71, B1PZ72, B1PZ73, B1PZ74 B1PZ75, B1PZ76, B1PZ77, B1PZ78, B1PZ79, |
UniProt Related Accession: | O75923 |
Molecular Weight: | |
NCBI Full Name: | dysferlin isoform 2 |
NCBI Synonym Full Names: | dysferlin |
NCBI Official Symbol: | DYSF |
NCBI Official Synonym Symbols: | MMD1; FER1L1; LGMD2B |
NCBI Protein Information: | dysferlin |
UniProt Protein Name: | Dysferlin |
UniProt Synonym Protein Names: | Dystrophy-associated fer-1-like protein; Fer-1-like protein 1 |
Protein Family: | Dysferlin |
UniProt Gene Name: | DYSF |
Antibodies | ELISA Kits |
DYSF Antibody (PACO05438) | Dysferlin Colorimetric Cell-Based ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |