DUSP19 Antibody (PACO39990)
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주문- SKU:
- PACO39990
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | DUSP19 Antibody (PACO39990) |
Antibody SKU: | PACO39990 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dual specificity protein phosphatase 19 protein (1-217AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO39990 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO39990 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO39990 at dilution of 1:100. |
Background: | Has a dual specificity toward Ser/Thr and Tyr-containing proteins. |
Synonyms: | Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1), DUSP19, DUSP17 LMWDSP3 SKRP1 |
UniProt Protein Function: | DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: cytoplasm Molecular Function:protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; protein amino acid dephosphorylation; inactivation of MAPK activity |
NCBI Summary: | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] |
UniProt Code: | Q8WTR2 |
NCBI GenInfo Identifier: | 29840769 |
NCBI Gene ID: | 142679 |
NCBI Accession: | Q8WTR2.1 |
UniProt Secondary Accession: | Q8WTR2,Q547H4, Q8WYN4, B2RA79, |
UniProt Related Accession: | Q8WTR2 |
Molecular Weight: | 217 |
NCBI Full Name: | Dual specificity protein phosphatase 19 |
NCBI Synonym Full Names: | dual specificity phosphatase 19 |
NCBI Official Symbol: | DUSP19 |
NCBI Official Synonym Symbols: | SKRP1; DUSP17; LMWDSP3; TS-DSP1 |
NCBI Protein Information: | dual specificity protein phosphatase 19; LMW-DSP3; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1 |
UniProt Protein Name: | Dual specificity protein phosphatase 19 |
UniProt Synonym Protein Names: | Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP19 |
UniProt Entry Name: | DUS19_HUMAN |