DUSP12 Antibody (PACO14396)
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주문- SKU:
- PACO14396
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DUSP12 Antibody (PACO14396) |
Antibody SKU: | PACO14396 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human DUSP12 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14396(DUSP12 Antibody) at dilution 1/77, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
Synonyms: | dual specificity phosphatase 12 |
UniProt Protein Function: | DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cytoplasm; nucleus Molecular Function:zinc ion binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; kinase binding Biological Process: protein modification process; protein amino acid dephosphorylation; positive regulation of glucokinase activity |
NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNI6 |
NCBI GenInfo Identifier: | 9973073 |
NCBI Gene ID: | 11266 |
NCBI Accession: | Q9UNI6.1 |
UniProt Secondary Accession: | Q9UNI6,Q9D0T2, |
UniProt Related Accession: | Q9UNI6 |
Molecular Weight: | 340 |
NCBI Full Name: | Dual specificity protein phosphatase 12 |
NCBI Synonym Full Names: | dual specificity phosphatase 12 |
NCBI Official Symbol: | DUSP12 |
NCBI Official Synonym Symbols: | YVH1; DUSP1 |
NCBI Protein Information: | dual specificity protein phosphatase 12; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase |
UniProt Protein Name: | Dual specificity protein phosphatase 12 |
UniProt Synonym Protein Names: | Dual specificity tyrosine phosphatase YVH1 |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP12 |
UniProt Entry Name: | DUS12_HUMAN |