DNMT3L Antibody (PACO14346)
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주문- SKU:
- PACO14346
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DNMT3L Antibody (PACO14346) |
Antibody SKU: | PACO14346 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human DNMT3L |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14346(DNMT3L Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14346(DNMT3L Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid, residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 α and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | DNA (cytosine-5-)-methyltransferase 3-like |
UniProt Code: | Q9UJW3 |
NCBI GenInfo Identifier: | 334302913 |
NCBI Gene ID: | 29947 |
NCBI Accession: | Q9UJW3.3 |
Molecular Weight: | 45kDa |
NCBI Full Name: | DNA (cytosine-5)-methyltransferase 3-like |
UniProt Protein Name: | DNA (cytosine-5)-methyltransferase 3-like |
Protein Family: | DNA (cytosine-5)-methyltransferase |
UniProt Gene Name: | DNMT3L |
UniProt Entry Name: | DNM3L_HUMAN |