DNAJC15 Antibody (PACO60889)
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주문- SKU:
- PACO60889
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DNAJC15 Antibody (PACO60889) |
Antibody SKU: | PACO60889 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DnaJ homolog subfamily C member 15 protein (59-150AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO60889 diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO60889 diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. |
Synonyms: | DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ), DNAJC15, DNAJD1 |
UniProt Protein Function: | DNAJC15: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes |
UniProt Protein Details: | Protein type:Chaperone; Membrane protein, integral; Cell adhesion; Mitochondrial Chromosomal Location of Human Ortholog: 13q14.1 Cellular Component: mitochondrial inner membrane; integral to membrane Biological Process: protein transport; regulation of lipid metabolic process; cellular response to starvation; negative regulation of protein complex assembly |
UniProt Code: | Q9Y5T4 |
NCBI GenInfo Identifier: | 110808202 |
NCBI Gene ID: | 29103 |
NCBI Accession: | Q9Y5T4.2 |
UniProt Secondary Accession: | Q9Y5T4,Q5T219, Q6X963, B2R4L0, |
UniProt Related Accession: | Q9Y5T4 |
Molecular Weight: | 16,383 Da |
NCBI Full Name: | DnaJ homolog subfamily C member 15 |
NCBI Synonym Full Names: | DnaJ (Hsp40) homolog, subfamily C, member 15 |
NCBI Official Symbol: | DNAJC15 |
NCBI Official Synonym Symbols: | MCJ; HSD18; DNAJD1 |
NCBI Protein Information: | dnaJ homolog subfamily C member 15; DNAJ domain-containing; DnaJ (Hsp40) homolog, subfamily D, member 1; cell growth-inhibiting gene 22 protein; methylation-controlled J protein |
UniProt Protein Name: | DnaJ homolog subfamily C member 15 |
UniProt Synonym Protein Names: | Cell growth-inhibiting gene 22 protein; Methylation-controlled J protein; MCJ |
Protein Family: | DnaJ homolog subfamily |
UniProt Gene Name: | DNAJC15 |
UniProt Entry Name: | DJC15_HUMAN |