DKK4 Antibody (PACO43659)
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주문- SKU:
- PACO43659
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DKK4 Antibody (PACO43659) |
Antibody SKU: | PACO43659 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Dickkopf-related protein 4 protein (19-224AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43659 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO43659 at dilution of 1:100. |
Background: | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
Synonyms: | Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form], DKK4 |
UniProt Protein Function: | DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. |
UniProt Protein Details: | Protein type:Inhibitor; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8p11.2-p11.1 Cellular Component: extracellular region Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; multicellular organismal development |
NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBT3 |
NCBI GenInfo Identifier: | 13124092 |
NCBI Gene ID: | 27121 |
NCBI Accession: | Q9UBT3.1 |
UniProt Secondary Accession: | Q9UBT3,Q3KNX0, Q9Y4C3, |
UniProt Related Accession: | Q9UBT3 |
Molecular Weight: | 24,876 Da |
NCBI Full Name: | Dickkopf-related protein 4 |
NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 4 |
NCBI Official Symbol: | DKK4 |
NCBI Official Synonym Symbols: | DKK-4 |
NCBI Protein Information: | dickkopf-related protein 4 |
UniProt Protein Name: | Dickkopf-related protein 4 |
Protein Family: | Dickkopf-related protein |
UniProt Gene Name: | DKK4 |
UniProt Entry Name: | DKK4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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