DKK3 Antibody (PACO14342)
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주문- SKU:
- PACO14342
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DKK3 Antibody (PACO14342) |
Antibody SKU: | PACO14342 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human DKK3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14342(DKK3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO14342(DKK3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14342(DKK3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. |
Synonyms: | dickkopf WNT signaling pathway inhibitor 3 |
UniProt Protein Function: | DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular space Biological Process: anatomical structure morphogenesis; Wnt receptor signaling pathway; adrenal gland development; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBP4 |
NCBI GenInfo Identifier: | 311033372 |
NCBI Gene ID: | 27122 |
NCBI Accession: | Q9UBP4.2 |
UniProt Secondary Accession: | Q9UBP4,Q9ULB7, A8K1I2, D3DQW1, |
UniProt Related Accession: | Q9UBP4 |
Molecular Weight: | 38,390 Da |
NCBI Full Name: | Dickkopf-related protein 3 |
NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 3 |
NCBI Official Symbol: | DKK3 |
NCBI Official Synonym Symbols: | RIG; REIC |
NCBI Protein Information: | dickkopf-related protein 3; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG-like 7-1; dickkopf 3 homolog; dickkopf homolog 3; regulated in glioma |
UniProt Protein Name: | Dickkopf-related protein 3 |
Protein Family: | Dickkopf-related protein |
UniProt Gene Name: | DKK3 |
UniProt Entry Name: | DKK3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |