DCXR Antibody (PACO44874)
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주문- SKU:
- PACO44874
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DCXR Antibody (PACO44874) |
Antibody SKU: | PACO44874 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human L-xylulose reductase protein (1-244AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: DCXR antibody at 2.93µg/ml. Lane 1: Mouse gonadal tissue. Lane 2: HepG2 whole cell lysate. Lane 3: A431 whole cell lysate. Lane 4: MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26 kDa. Observed band size: 26 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44874 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO44874 at dilution of 1:100. |
Background: | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
Synonyms: | L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H), DCXR, SDR20C1 |
UniProt Protein Function: | DCXR: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 1.1.1.10 Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: microvillus; membrane; cytoplasmic microtubule; nucleus; brush border Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; L-xylulose reductase activity Biological Process: glucose metabolic process; xylulose metabolic process; D-xylose metabolic process; NADP metabolic process; protein homotetramerization Disease: Pentosuria |
NCBI Summary: | The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] |
UniProt Code: | Q7Z4W1 |
NCBI GenInfo Identifier: | 50400451 |
NCBI Gene ID: | 51181 |
NCBI Accession: | Q7Z4W1.2 |
UniProt Related Accession: | Q7Z4W1 |
Molecular Weight: | |
NCBI Full Name: | L-xylulose reductase |
NCBI Synonym Full Names: | dicarbonyl and L-xylulose reductase |
NCBI Official Symbol: | DCXR |
NCBI Official Synonym Symbols: | XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1 |
NCBI Protein Information: | L-xylulose reductase |
UniProt Protein Name: | L-xylulose reductase |
UniProt Synonym Protein Names: | Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H |
UniProt Gene Name: | DCXR |
UniProt Entry Name: | DCXR_HUMAN |