DCAF7 Antibody (PACO43602)
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주문- SKU:
- PACO43602
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DCAF7 Antibody (PACO43602) |
Antibody SKU: | PACO43602 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DDB1- and CUL4-associated factor 7 protein (1-342AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43602 at dilution of 1:100. |
Background: | Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. |
Synonyms: | DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog), DCAF7, HAN11 WDR68 |
UniProt Protein Function: | WDR68: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: cytoplasm; nuclear matrix; nucleoplasm; protein complex Molecular Function:protein binding Biological Process: protein ubiquitination |
NCBI Summary: | This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
UniProt Code: | P61962 |
NCBI GenInfo Identifier: | 48428729 |
NCBI Gene ID: | 10238 |
NCBI Accession: | P61962.1 |
UniProt Secondary Accession: | P61962,O15491, Q9DAE4, B4E039, D3DU14, |
UniProt Related Accession: | P61962 |
Molecular Weight: | 16,340 Da |
NCBI Full Name: | DDB1- and CUL4-associated factor 7 |
NCBI Synonym Full Names: | DDB1 and CUL4 associated factor 7 |
NCBI Official Symbol: | DCAF7 |
NCBI Official Synonym Symbols: | AN11; HAN11; WDR68; SWAN-1 |
NCBI Protein Information: | DDB1- and CUL4-associated factor 7 |
UniProt Protein Name: | DDB1- and CUL4-associated factor 7 |
UniProt Synonym Protein Names: | WD repeat-containing protein 68; WD repeat-containing protein An11 homolog |
Protein Family: | DDB1- and CUL4-associated factor |
UniProt Gene Name: | DCAF7 |
UniProt Entry Name: | DCAF7_HUMAN |