DCAF6 Antibody (PACO20131)
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주문- SKU:
- PACO20131
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DCAF6 Antibody (PACO20131) |
Antibody SKU: | PACO20131 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human DCAF6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20131(DCAF6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20131(DCAF6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | NRIP (Nuclear receptor interaction protein), also known as IQWD1 ( IQ motif and WD repeat-containing protein 1), MSTP055, ARCAP or PC326, is an 860 amino acid, protein that localizes to the nucleus and contains one IQ domain and seven WD-repeats. Expressed in testis, skeletal muscle, prostate and heart, NRIP functions as a ligand-dependent coactivator of nuclear receptors and specifically enhances the transcriptional activity of AR (androgen receptor) and GR (glucocorticoid receptor). NRIP exists as three isoforms that are produced by alternative splicing events. |
Synonyms: | DDB1 and CUL4 associated factor 6 |
UniProt Protein Function: | MSTP055: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: nucleoplasm; focal adhesion; cytoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity Biological Process: protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter |
UniProt Code: | Q58WW2 |
NCBI GenInfo Identifier: | 74755134 |
NCBI Gene ID: | 55827 |
NCBI Accession: | Q58WW2.1 |
UniProt Secondary Accession: | Q58WW2,Q7L8I0, Q8IXH3, Q8TB19, A2A295, B4DNB8, |
UniProt Related Accession: | Q58WW2 |
Molecular Weight: | 103,070 Da |
NCBI Full Name: | DDB1- and CUL4-associated factor 6 |
NCBI Synonym Full Names: | DDB1 and CUL4 associated factor 6 |
NCBI Official Symbol: | DCAF6 |
NCBI Official Synonym Symbols: | NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik |
NCBI Protein Information: | DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; androgen receptor complex-associated protein; nuclear receptor interaction protein |
UniProt Protein Name: | DDB1- and CUL4-associated factor 6 |
UniProt Synonym Protein Names: | Androgen receptor complex-associated protein; ARCAP; IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein; NRIP |
Protein Family: | DDB1- and CUL4-associated factor |
UniProt Gene Name: | DCAF6 |
UniProt Entry Name: | DCAF6_HUMAN |