CYP46A1 Antibody (PACO19531)
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주문- SKU:
- PACO19531
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP46A1 Antibody (PACO19531) |
Antibody SKU: | PACO19531 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human CYP46A1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19531(CYP46A1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO19531(CYP46A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19531(CYP46A1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. |
Synonyms: | cytochrome P450, family 46, subfamily A, polypeptide 1 |
UniProt Protein Function: | CSTB: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1). EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop. Belongs to the cystatin family. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: extracellular space; cytoplasm; nucleolus Molecular Function:protease binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity Biological Process: negative regulation of proteolysis; regulation of apoptosis; adult locomotory behavior; negative regulation of peptidase activity Disease: Myoclonic Epilepsy Of Unverricht And Lundborg |
UniProt Code: | Q9Y6A2 |
NCBI GenInfo Identifier: | 5729796 |
NCBI Gene ID: | 10858 |
NCBI Accession: | NP_006659 |
UniProt Secondary Accession: | Q9Y6A2,Q8N2B0, B4DHP8, E7EQG9, |
UniProt Related Accession: | Q9Y6A2 |
Molecular Weight: | 38,315 Da |
NCBI Full Name: | cholesterol 24-hydroxylase |
NCBI Synonym Full Names: | cytochrome P450, family 46, subfamily A, polypeptide 1 |
NCBI Official Symbol: | CYP46A1 |
NCBI Official Synonym Symbols: | CP46; CYP46 |
NCBI Protein Information: | cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) |
UniProt Protein Name: | Cystatin-B |
UniProt Synonym Protein Names: | CPI-B; Liver thiol proteinase inhibitor; Stefin-B |
Protein Family: | Cystatin |
UniProt Gene Name: | CSTB |
UniProt Entry Name: | CYTB_HUMAN |