CYP27A1 Antibody (PACO55310)
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주문- SKU:
- PACO55310
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP27A1 Antibody (PACO55310) |
Antibody SKU: | PACO55310 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Sterol 26-hydroxylase, mitochondrial protein (290-407AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO55310 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO55310 at dilution of 1:100. |
Background: | Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. |
Synonyms: | Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase), CYP27A1, CYP27 |
UniProt Protein Function: | CYP27A1: Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity. Defects in CYP27A1 are the cause of cerebrotendinous xanthomatosis (CTX). CTX is a rare sterol storage disorder characterized clinically by progressive neurologic dysfunction, premature atherosclerosis, and cataracts. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis; EC 1.14.13.15; Mitochondrial Chromosomal Location of Human Ortholog: 2q35 Cellular Component: mitochondrial matrix; mitochondrial inner membrane Molecular Function:cholestanetriol 26-monooxygenase activity; iron ion binding; cholesterol 26-hydroxylase activity; heme binding; steroid hydroxylase activity; vitamin D3 25-hydroxylase activity Biological Process: bile acid biosynthetic process; cholesterol metabolic process; bile acid metabolic process; xenobiotic metabolic process; sterol metabolic process Disease: Cerebrotendinous Xanthomatosis |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q02318 |
NCBI GenInfo Identifier: | 4503211 |
NCBI Gene ID: | 1593 |
NCBI Accession: | NP_000775.1 |
UniProt Related Accession: | Q02318 |
Molecular Weight: | Predicted Molecular Mass: 39kDaAccurate Molecular Mass: 43kDa |
NCBI Full Name: | sterol 26-hydroxylase, mitochondrial |
NCBI Synonym Full Names: | cytochrome P450 family 27 subfamily A member 1 |
NCBI Official Symbol: | CYP27A1 |
NCBI Official Synonym Symbols: | CTX; CP27; CYP27 |
NCBI Protein Information: | sterol 26-hydroxylase, mitochondrial |
UniProt Protein Name: | Sterol 26-hydroxylase, mitochondrial |
UniProt Synonym Protein Names: | 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase |
Protein Family: | FK506-binding protein |
UniProt Gene Name: | CYP27A1 |
UniProt Entry Name: | CP27A_HUMAN |
Antibodies | ELISA Kits |
Anti-CYP27A1 Antibody (CAB1982) | Cytochrome P450 27A1 Colorimetric Cell-Based ELISA |
CYP27A1 Antibody (PACO00662) | |
CYP27A1 Antibody (PACO08712) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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