CYP21A2 Antibody (PACO16116)
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주문- SKU:
- PACO16116
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP21A2 Antibody (PACO16116) |
Antibody SKU: | PACO16116 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human CYP21A2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16116(CYP21A2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16116(CYP21A2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | cytochrome P450, family 21, subfamily A, polypeptide 2 |
UniProt Protein Function: | CYP21A2: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3). AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Lipid Metabolism - C21-steroid hormone; EC 1.14.99.10 Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endoplasmic reticulum membrane Molecular Function:heme binding; steroid 21-monooxygenase activity; steroid hydroxylase activity Biological Process: glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process; steroid metabolic process; sterol metabolic process Disease: Adrenal Hyperplasia, Congenital, Due To 21-hydroxylase Deficiency |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08686 |
NCBI GenInfo Identifier: | 117275 |
NCBI Gene ID: | 1589 |
NCBI Accession: | P08686.1 |
UniProt Secondary Accession: | P08686,P04033, Q01204, Q08AG8, Q16749, Q16806, Q5ST44 Q96NU8, A2BHY6, |
UniProt Related Accession: | P08686 |
Molecular Weight: | 52,597 Da |
NCBI Full Name: | Steroid 21-hydroxylase |
NCBI Synonym Full Names: | cytochrome P450 family 21 subfamily A member 2 |
NCBI Official Symbol: | CYP21A2 |
NCBI Official Synonym Symbols: | CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B |
NCBI Protein Information: | steroid 21-hydroxylase |
UniProt Protein Name: | Steroid 21-hydroxylase |
UniProt Synonym Protein Names: | 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B |
UniProt Gene Name: | CYP21A2 |
UniProt Entry Name: | CP21A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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