CYP19A1 Antibody (PACO17604)
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주문- SKU:
- PACO17604
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CYP19A1 Antibody (PACO17604) |
Antibody SKU: | PACO17604 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human CYP19A1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17604(CYP19A1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17604(CYP19A1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity, the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. |
Synonyms: | cytochrome P450, family 19, subfamily A, polypeptide 1 |
UniProt Protein Function: | CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. |
UniProt Protein Details: | Protein type:EC 1.14.14.14; Oxidoreductase; Lipid Metabolism - androgen and estrogen Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane Molecular Function:electron carrier activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity Biological Process: estrogen biosynthetic process; steroid biosynthetic process; sterol metabolic process Disease: Aromatase Deficiency; Aromatase Excess Syndrome |
NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
UniProt Code: | P11511 |
NCBI GenInfo Identifier: | 117293 |
NCBI Gene ID: | 1588 |
NCBI Accession: | P11511.3 |
UniProt Secondary Accession: | P11511,Q16731, Q3B764, Q58FA0, Q8IYJ7, |
UniProt Related Accession: | P11511 |
Molecular Weight: | 24,518 Da |
NCBI Full Name: | Aromatase |
NCBI Synonym Full Names: | cytochrome P450 family 19 subfamily A member 1 |
NCBI Official Symbol: | CYP19A1 |
NCBI Official Synonym Symbols: | ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM |
NCBI Protein Information: | aromatase |
UniProt Protein Name: | Aromatase |
UniProt Synonym Protein Names: | CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase |
Protein Family: | Aromatase |
UniProt Gene Name: | CYP19A1 |
UniProt Entry Name: | CP19A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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