UniProt Protein Function: | CXXC1: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 18q12 Cellular Component: cytoplasm; histone methyltransferase complex; nuclear speck; nucleoplasm; nucleus Molecular Function:histone lysine N-methyltransferase activity (H3-K4 specific); protein binding; unmethylated CpG binding Biological Process: histone H3-K4 methylation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9P0U4 |
NCBI GenInfo Identifier: | 20138037 |
NCBI Gene ID: | 30827 |
NCBI Accession: | Q9P0U4.2 |
UniProt Secondary Accession: | Q9P0U4,Q8N2W4, Q96BC8, Q9P2V7, B2RC03, |
UniProt Related Accession: | Q9P0U4 |
Molecular Weight: | 76,227 Da |
NCBI Full Name: | CXXC-type zinc finger protein 1 |
NCBI Synonym Full Names: | CXXC finger protein 1 |
NCBI Official Symbol: | CXXC1 |
NCBI Official Synonym Symbols: | CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik |
NCBI Protein Information: | CXXC-type zinc finger protein 1 |
UniProt Protein Name: | CXXC-type zinc finger protein 1 |
UniProt Synonym Protein Names: | CpG-binding protein; PHD finger and CXXC domain-containing protein 1 |
Protein Family: | CXXC-type zinc finger protein |
UniProt Gene Name: | CXXC1 |
UniProt Entry Name: | CXXC1_HUMAN |