CUL5 Antibody (PACO14298)
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주문- SKU:
- PACO14298
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CUL5 Antibody (PACO14298) |
Antibody SKU: | PACO14298 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human CUL5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14298(CUL5 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |
Synonyms: | cullin 5 |
UniProt Protein Function: | CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: Cul5-RING ubiquitin ligase complex; cytosol Molecular Function:calcium channel activity; protein binding; receptor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: cell cycle arrest; cell proliferation; G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; protein ubiquitination during ubiquitin-dependent protein catabolic process |
UniProt Code: | Q93034 |
NCBI GenInfo Identifier: | 14917099 |
NCBI Gene ID: | 8065 |
NCBI Accession: | Q93034.4 |
UniProt Secondary Accession: | Q93034,O14766, Q9BZC6, A8K960, |
UniProt Related Accession: | Q93034 |
Molecular Weight: | 90,955 Da |
NCBI Full Name: | Cullin-5 |
NCBI Synonym Full Names: | cullin 5 |
NCBI Official Symbol: | CUL5 |
NCBI Official Synonym Symbols: | VACM1; VACM-1 |
NCBI Protein Information: | cullin-5 |
UniProt Protein Name: | Cullin-5 |
UniProt Synonym Protein Names: | Vasopressin-activated calcium-mobilizing receptor 1; VACM-1 |
Protein Family: | Cullin |
UniProt Gene Name: | CUL5 |
UniProt Entry Name: | CUL5_HUMAN |
Antibodies | ELISA Kits |
Anti-CUL5 Antibody (CAB5369) | Human VACM-1(Cullin 5) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |