CST6 Antibody (PACO16127)
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주문- SKU:
- PACO16127
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CST6 Antibody (PACO16127) |
Antibody SKU: | PACO16127 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human CST6 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16127(CST6 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16127(CST6 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. |
Synonyms: | cystatin E/M |
UniProt Protein Function: | CST6: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Belongs to the cystatin family. |
UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cornified envelope Molecular Function:cysteine protease inhibitor activity Biological Process: epidermis development; anatomical structure morphogenesis |
NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15828 |
NCBI GenInfo Identifier: | 4503113 |
NCBI Gene ID: | 1474 |
NCBI Accession: | NP_001314.1 |
UniProt Secondary Accession: | Q15828,Q540N7, |
UniProt Related Accession: | Q15828 |
Molecular Weight: | 16,511 Da |
NCBI Full Name: | cystatin-M |
NCBI Synonym Full Names: | cystatin E/M |
NCBI Official Symbol: | CST6 |
NCBI Protein Information: | cystatin-M; cystatin 6; cystatin M; cystatin-6; cystatin-E; cystatin M/E; cysteine proteinase inhibitor |
UniProt Protein Name: | Cystatin-M |
UniProt Synonym Protein Names: | Cystatin-6; Cystatin-E |
Protein Family: | Cystatin |
UniProt Gene Name: | CST6 |
UniProt Entry Name: | CYTM_HUMAN |