CRMP1 Antibody (PACO17724)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO17724
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CRMP1 Antibody (PACO17724) |
Antibody SKU: | PACO17724 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human CRMP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse brain tissue, Primary antibody: PACO17724(CRMP1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17724(CRMP1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family. This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. CRMP1 mediates reelin signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory. CRMP1 gene overlaps with another gene called EVC. CRMP1 has been shown to interact with DPYSL2. |
Synonyms: | collapsin response mediator protein 1 |
UniProt Protein Function: | CRMP-1: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Cytoskeletal; Hydrolase Chromosomal Location of Human Ortholog: 4p16.1 Cellular Component: cell soma; cytoplasm; dendrite; microtubule organizing center; spindle; cytosol Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; protein binding Biological Process: axon guidance; nervous system development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine base catabolic process |
NCBI Summary: | This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14194 |
NCBI GenInfo Identifier: | 3122031 |
NCBI Gene ID: | 1400 |
NCBI Accession: | Q14194.1 |
UniProt Secondary Accession: | Q14194,Q13024, Q4W5F1, Q96TC8, A0EJG6, |
UniProt Related Accession: | Q14194 |
Molecular Weight: | 572 |
NCBI Full Name: | Dihydropyrimidinase-related protein 1 |
NCBI Synonym Full Names: | collapsin response mediator protein 1 |
NCBI Official Symbol: | CRMP1 |
NCBI Official Synonym Symbols: | DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3 |
NCBI Protein Information: | dihydropyrimidinase-related protein 1; dihydropyrimidinase-like 1; unc-33-like phosphoprotein 3 |
UniProt Protein Name: | Dihydropyrimidinase-related protein 1 |
UniProt Synonym Protein Names: | Collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3; ULIP-3 |
Protein Family: | Dihydropyrimidinase-related protein |
UniProt Gene Name: | CRMP1 |
UniProt Entry Name: | DPYL1_HUMAN |