CRLF2 Antibody (PACO19495)
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주문- SKU:
- PACO19495
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CRLF2 Antibody (PACO19495) |
Antibody SKU: | PACO19495 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CRLF2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19495(CRLF2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19495(CRLF2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | cytokine receptor-like factor 2 |
UniProt Protein Function: | CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2 |
NCBI Summary: | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q9HC73 |
NCBI GenInfo Identifier: | 38257768 |
NCBI Gene ID: | 64109 |
NCBI Accession: | Q9HC73.1 |
UniProt Secondary Accession: | Q9HC73,Q5G7M1, Q9H5R3, J3QKD1, |
UniProt Related Accession: | Q9HC73 |
Molecular Weight: | 29,360 Da |
NCBI Full Name: | Cytokine receptor-like factor 2 |
NCBI Synonym Full Names: | cytokine receptor-like factor 2 |
NCBI Official Symbol: | CRLF2 |
NCBI Official Synonym Symbols: | CRL2; TSLPR; CRLF2Y |
NCBI Protein Information: | cytokine receptor-like factor 2 |
UniProt Protein Name: | Cytokine receptor-like factor 2 |
UniProt Synonym Protein Names: | Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor |
Protein Family: | Thymic stromal lymphopoietin |
UniProt Gene Name: | CRLF2 |
Antibodies | ELISA Kits |
Anti-CRLF2 Antibody (CAB10152) | Human CRLF2 (Cardiotrophin-like cytokine factor 2) ELISA Kit (HUFI03417) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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