CRADD Antibody (PACO43920)
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주문- SKU:
- PACO43920
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CRADD Antibody (PACO43920) |
Antibody SKU: | PACO43920 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Death domain-containing protein CRADD protein (1-199AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO43920 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43920 at dilution of 1:100. |
Background: | Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. |
Synonyms: | Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain), CRADD, RAIDD |
UniProt Protein Function: | CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Chromosomal Location of Human Ortholog: 12q21.33-q23.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding, bridging; protein binding; protease binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Disease: Mental Retardation, Autosomal Recessive 34 |
NCBI Summary: | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
UniProt Code: | P78560 |
NCBI GenInfo Identifier: | 2498833 |
NCBI Gene ID: | 8738 |
NCBI Accession: | P78560.1 |
UniProt Related Accession: | P78560 |
Molecular Weight: | ~ 23kDa |
NCBI Full Name: | Death domain-containing protein CRADD |
NCBI Synonym Full Names: | CASP2 and RIPK1 domain containing adaptor with death domain |
NCBI Official Symbol: | CRADD |
NCBI Official Synonym Symbols: | MRT34; RAIDD |
NCBI Protein Information: | death domain-containing protein CRADD |
UniProt Protein Name: | Death domain-containing protein CRADD |
UniProt Synonym Protein Names: | Caspase and RIP adapter with death domain; RIP-associated protein with a death domain |
UniProt Gene Name: | CRADD |
UniProt Entry Name: | CRADD_HUMAN |