CPE Antibody (PACO57712)
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주문- SKU:
- PACO57712
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CPE Antibody (PACO57712) |
Antibody SKU: | PACO57712 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Carboxypeptidase E protein (252-363AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A375 whole cell lysate. All lanes: CPE antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54, 50 kDa. Observed band size: 54 kDa. |
Background: | Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. |
Synonyms: | Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase), CPE |
UniProt Protein Function: | CPE: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.17.10; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q32.3 Cellular Component: cell soma; extracellular space; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane Molecular Function:carboxypeptidase activity; cell adhesion molecule binding; metallocarboxypeptidase activity; neurexin binding; serine carboxypeptidase activity Biological Process: insulin processing; metabolic process; Wnt receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] |
UniProt Code: | P16870 |
NCBI GenInfo Identifier: | 115892 |
NCBI Gene ID: | 1363 |
NCBI Accession: | P16870.1 |
UniProt Secondary Accession: | P16870,Q9UIU9, A8K4N1, B3KR42, B4DFN4, D3DP33, |
UniProt Related Accession: | P16870 |
Molecular Weight: | 49,886 Da |
NCBI Full Name: | Carboxypeptidase E |
NCBI Synonym Full Names: | carboxypeptidase E |
NCBI Official Symbol: | CPE |
NCBI Official Synonym Symbols: | CPH |
NCBI Protein Information: | carboxypeptidase E |
UniProt Protein Name: | Carboxypeptidase E |
UniProt Synonym Protein Names: | Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase |
Protein Family: | Carboxypeptidase |
UniProt Gene Name: | CPE |
UniProt Entry Name: | CBPE_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |