COL4A3BP Antibody (PACO42742)
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주문- SKU:
- PACO42742
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | COL4A3BP Antibody (PACO42742) |
Antibody SKU: | PACO42742 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Collagen type IV alpha-3-binding protein (201-500AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse kidney tissue, Mouse stomach tissue, Mouse thymus tissue. All lanes: COL4A3BP antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71, 69, 84 kDa. Observed band size: 71 kDa. | |
Immunofluorescent analysis of Hela cells using PACO42742 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO42742 at dilution of 1:100. |
Background: | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
Synonyms: | Collagen type IV alpha-3-binding protein (Ceramide transfer protein) (hCERT) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11), COL4A3BP, CERT STARD11 |
UniProt Protein Function: | COL4A3BP: a protein with a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. Implicated in human autoimmune diseases via its association with the Goodpasture antigen. Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. GPBP has been reported to have Ser/Thr protein kinase activity towards the Goodpasture (GP) antigen, but lacks a conventional serine/threonine kinase domain. Two human isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.9; Lipid-binding; Protein kinase, atypical; ATYPICAL group; COL4A3BP family Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; cytosol Molecular Function:protein binding; protein kinase activity Biological Process: heart morphogenesis; endoplasmic reticulum organization and biogenesis; cell proliferation; sphingolipid metabolic process; muscle contraction; sphingolipid biosynthetic process; in utero embryonic development; cell morphogenesis; lipid homeostasis; immune response; signal transduction; ceramide metabolic process; protein amino acid phosphorylation Disease: Mental Retardation, Autosomal Dominant 34 |
NCBI Summary: | This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5P4 |
NCBI GenInfo Identifier: | 20978413 |
NCBI Gene ID: | 10087 |
NCBI Accession: | Q9Y5P4.1 |
UniProt Secondary Accession: | Q9Y5P4,Q53YV1, Q53YV2, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8 A8K7S2, B3KUB7, |
UniProt Related Accession: | Q9Y5P4 |
Molecular Weight: | 83,708 Da |
NCBI Full Name: | Collagen type IV alpha-3-binding protein |
NCBI Synonym Full Names: | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
NCBI Official Symbol: | COL4A3BP |
NCBI Official Synonym Symbols: | CERT; GPBP; CERTL; STARD11 |
NCBI Protein Information: | collagen type IV alpha-3-binding protein; hCERT; ceramide transporter; ceramide transfer protein; lipid-transfer protein CERTL; StAR-related lipid transfer (START) domain containing 11 |
UniProt Protein Name: | Collagen type IV alpha-3-binding protein |
UniProt Synonym Protein Names: | Ceramide transfer protein; hCERT; Goodpasture antigen-binding protein; GPBP; START domain-containing protein 11; StARD11; StAR-related lipid transfer protein 11 |
Protein Family: | Collagen type IV alpha-3-binding protein |
UniProt Gene Name: | COL4A3BP |
UniProt Entry Name: | C43BP_HUMAN |
Antibodies | ELISA Kits |
Anti-COL4A3BP Antibody (CAB15376) | Human COL4A3BP / Collagen type IV alpha 3 binding protein ELISA Kit |
COL4A3BP Antibody (PACO08512) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |